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Image Number 1021 (Glomus tumour)


Diagnosis: Glomus tumour

Site: Knee

Sex: F

Age: 24

Type: Histology

Description: H-E stain (10X magnification) showing glomus cells, spindle cells and vascular spaces.

Submitted by: Nameer Al-Sudany

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Differential Diagnosis


Glomus tumors consist of varying proportions of glomus cells, blood vessels, and smooth muscle and accordingly they are classified into solid glomus tumor, glomangioma and glomangiomyoma. Glomus tumors are well circumscribed, and a solid lesion is composed of sheets of uniform cells with pale or eosinophilic cytoplasm and round or ovoid central nuclei. Cytologic atypia is usually absent and small blood vessels are uniformly distributed in the tumor. In glomangioma, there are numerous cavernous vascular spaces surrounded by one or a few layers of glomus cells. In glomangiomyoma, an important number of spindle-shaped smooth-muscle cells are found and tend to be distributed near the vascular spaces and blend with the adjacent collections of glomus cells. Here is a case of glomangiomyoma composed of sheets of glomus cells combined with many spindle-shaped smooth muscle cells with pink cytoplasm and many vascular channels.

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