Neonatal acneiform facial lesions usually develop within the first 30 days of life and are estimated to occur in 50 percent of newborns. Neonatal acne is marked by small, inflamed papules across the nasal bridge and on the cheeks. Comedone formation is absent. This benign eruption appears to be hormonally mediated. Neonatal acne may be hard to distinguish from benign neonatal cephalic pustulosis, which has been attributed to overgrowth of Malassezia sympodialis, a normal commensal on human skin. Most cases of neonatal acne resolve spontaneously within 3 months, but severe cases can be treated topically with ketoconazole, benzoyl peroxide, or erythromycin. The presented case is 24-day-old neonate developed papulopustular rash on the central parts of both cheeks and forehead at age of 10 days.