Pyogenic granuloma is a benign vascular lesion of unknown etiology that may involve skin and mucosa. Trauma, hormonal influences, viral oncogenes, underlying microscopic arteriovenous malformations, and the production of angiogenic growth factors have all been postulated to play a role in the pathogenesis of pyogenic granuloma. The typical solitary lesion is a bright red, friable polypoid papule or nodule ranging from a few millimeters to several centimeters. The head, neck, digits, and upper trunk are affected most commonly. The common solitary pyogenic granuloma grows rapidly to its maximum size over a period of a few weeks. Shave, punch, scalpel, or laser excision may be curative.