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Image Number 2113 (Acrokeratosis verruciformis of Hopf)


Diagnosis: Acrokeratosis verruciformis of Hopf

Site: Hand,dorsum

Sex: F

Age: 40


Description: Grouped flat papules.

Submitted by: Nameer Al-Sudany

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Differential Diagnosis


Acrokeratosis verruciformis of Hopf is a rare autosomal-dominant genodermatosis characterized by numerous flat verrucous papules occurring on the backs of the hands, insteps, knees, and elbows. The papules are closely grouped and resemble warts except that they are flatter and more localized. It is allelic to Darier's disease (caused by mutations in the same gene). The skin biopsy pf the presented patient showed hyperkeratosis, thickening of the granular layer, acanthosis and church spire papillomatosis.

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