Home | Recent Submissions | Search | Diagnosis | Quiz | Submit an Image | Index | Blog |About GSA
  
<< Back to Diagnosis Page  
Image Number 2491 (Epidermodysplasia verruciformis)

 
Morphology:
Warty

Diagnosis: Epidermodysplasia verruciformis

Site: Back

Sex: M

Age: 47

Type:

Description: Pityriasis versicolor-like lesions.

Submitted by: Nameer Al-Sudany

View Full Size

Differential Diagnosis

History:

        A middle-aged man presented with widespread, asymptomatic, indolent wart-like lesions involved the face, dorsa of the hands and trunk in addition to hypopigmented-pinkish flat scaly lesions resembled pityriasis versicolor on the upper back. The condition started since early childhood and the patient has negative family history of similar condition.   

      Epidermodysplasia verruciformis or also known as Lewandowsky–Lutz disease is a rare chronic HPV infection with specific autosomal recessive immune defect. The patients are infected by a series of different HPV types, some of which are carcinogenic. In childhood patients develop multiple warts and large flat lesions resembling tinea versicolor, with no tendency to spontaneous regression. Later Bowen disease and SCC, primarily in sun-exposed skin. Diagnostic approach: Clinical findings; HPV typing and genetic studies essential. The main differential diagnosis is widespread warts in immunosuppressed individuals, such as posttransplantation or HIV/AIDS. Careful monitoring and compulsive use of sunscreens are recommended and both imiquimod and topical 5-FU may be helpful. Systemic retinoids for prophylaxis may be useful.



Search DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Epidermodysplasia verruciformis"

buy accutane
Home  |  Recent Submissions  |  Search  | Diagnosis  |  Quiz  |  Submit an Image  |  Index  |  About GSA

Copyright © 2005 Global Skin Atlas