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Image Number 2508 (Kyrle disease)

 
Morphology:
Papules

Diagnosis: Kyrle disease

Site: Knee

Sex: F

Age: 45

Type:

Description: Keratotic papules at the knee

Submitted by: Ian McColl

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Differential Diagnosis

History:

This patient had diabetes and renal failure. She had developed these papules over a period of 12 months. They were itchy.This is Kyrle disease, or acquired perforating dermatosis.The characteristic papules have a keratotic plug made up of neutrophils with eliminated collagen and elastin which is being expelled through the epidermis. It is usually seen on the extensor surfaces of the lower extremities. The condition can completely disappear after renal transplantation.



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