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Image Number 292 (Systemic amyloidosis)


Diagnosis: Systemic amyloidosis

Site: Tongue

Sex: F

Age: 75

Type: Clinical

Description: Swollen tongue

Submitted by: Ian McColl

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Differential Diagnosis


Systemic amyloidosis is usually asssociated with underlying plasma cell dyscrasias.In this lady's case she had Multiple myeloma.The fibrils of amyloid are made up of immunoglobulin light chains which infiltrate superficial blood vessels causing hemorrhage with mild trauma.The tongue can be uniformly thickened or studded with papules or plaques of amyloid.

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