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Image Number 303 (Minocycline pigmentation)

 
Morphology:
Hyperpigmentation

Diagnosis: Minocycline pigmentation

Site: Neck nape

Sex: M

Age: 62

Type: Clinical

Description: Typical slate grey pigmentation

Submitted by: Ian McColl

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Differential Diagnosis

History: Minocycline pigmentation can present in three ways namely as pigmentation of acne scars,or as diffuse pigmentation of the lower limbs or as a diffuse generalised hyperpigmentation.The latter two presentations seem to be dose related but not the former.In addition to the skin Minocycline can be deposited in cartilage,conjunctivae,bone,sclerae and teeth.After stopping the drug it can take years for the pigmentation to fade.The leg ulceration being treated with Minocycline was caused by Pyoderma gangrenosum.

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