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Image Number 349 (Addison's disease)

 
Morphology:
Hyperpigmentation

Diagnosis: Addison's disease

Site: Mouth

Sex: F

Age: 72

Type: Clinical

Description: Pigmentation of the buccal mucosae

Submitted by: Ian McColl

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Differential Diagnosis

History:

This is the mucosal pigmentation of Addison's disease.Pigmentation also occurs in sun exposed areas of the skin and areas of pressure or trauma.Involvement of the palmar creases is a characteristic feature.Addison's disease can have many causes including tuberculosis,bilateral metastases and can also be part of a polyglandular autoimmune disease.

Patients become progressively  weak with increasing hypotension and hyperpigmentation.



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