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Image Number 392 (Granuloma inguinale)

 
Morphology:
Ulcer

Diagnosis: Granuloma inguinale

Site: Penis

Sex: M

Age: 24

Type: Clinical

Description: Slowly growing painless vascular ulcer

Submitted by: Ian McColl

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Differential Diagnosis

History: Granuloma inguinale is a chronic progressive ulcerating genital disease caused by Calymmatobacterium granulomatis,a gram negative bacillus.The micro organism was first identified by Donovan in 1905 and hence its other name of Donovanosis.The initial lesion is a small papule or nodule that subsequently ulcerates.The ulcers are vascular with a beefy red appearance and a tendency to bleed.The causative organisms are best found in smears rather than biopsies.They are seen in parasitised histiocytes similar to leishmaniasis.The recommended treatment is doxycycline and trimethoprim-sulfamethoxazole for at least 3 weeks.

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