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Image Number 441 (Systemic sclerosis)

Skin coloured,nonscaly

Diagnosis: Systemic sclerosis

Site: Hand,dorsum

Sex: M

Age: 40

Type: Clinical

Description: Sclerosis leading to contractures

Submitted by: Shahbaz Janjua

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Differential Diagnosis

History: Systemic sclerosis is a systemic connective tissue disorder which affects the connective tissue of the skin and internal organs such as gastrointestinal tract, lungs, heart and kidneys. It is characterized by alterations of the microvasculature, disturbances of the immune system and by massive deposition of collagen.

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