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Image Number 45 (Pemphigoid bullous)

 
Morphology:
Blisters

Diagnosis: Pemphigoid bullous

Site: Thigh

Sex: F

Age: 70

Type: Clinical

Description: Blisters on an inflammed base

Submitted by: Ian McColl

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Differential Diagnosis

History: This elderly lady initially had an itchy urticarial rash on her trunk and limbs but after a few weeks she suddenly developed these tense grouped blisters.Immunofluorescence showed IgG and C3 deposited on the basement membrane.She responded rapidly to oral steroids and subsequently Imuran as a steroid sparer was used along with topical steroids to any small areas of skin where the urticarial rash was recurring.

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