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Image Number 453 (Peutz-Jeghers syndrome)

 
Morphology:
Hyperpigmentation

Diagnosis: Peutz-Jeghers syndrome

Site: Lips

Sex: M

Age: 56

Type: Clinical

Description: Pigmented macules on the lips

Submitted by: Ian McColl

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Differential Diagnosis

History: Peutz-Jeghers syndrome has hyperpigmented macules on the lips and oral mucosa in association with polyps of the small intestine.The malignant transformation rate of these polyps is about 3 %.Patients with Peutz-Jeghers also have an increased risk of developing other malignancies particularly breast and gynae malignancies in women.The condition is inherited as an autosomal dominant.

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