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Image Number 4811 (Sign of Leser-Trelat)


Diagnosis: Sign of Leser-Trelat

Site: Back

Sex: M

Age: 55


Description: Multiple seborrheic keratoses

Submitted by: Shahbaz Janjua

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Differential Diagnosis


Sign of Leser-Trelat, or eruptive seborrheic keratosis, is defined as the association of the abrupt appearance of multiple seborrheic keratoses, often pruritic, with an underlying internal malignancy. This sign has been regarded as a rare but reliable cutaneous marker of internal malignancy. The pathogenesis of the sign of Leser-Trelat is still unknown. The sign is not widely accepted as a paraneoplastic syndrome because seborrheic keratoses and cancer are common findings in the elderly.


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