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Image Number 601 (Ochronosis)

 
Morphology:
Patch

Diagnosis: Ochronosis

Site: Face

Sex: F

Age: 35

Type: Clinical

Description: Ochronosis caused by topical use of hydroquinone for several months

Submitted by: Shahbaz Janjua

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Differential Diagnosis

History: Ochronosis is characterised by the bluish black discoloration of certain tissues caused by the deposition of homogentisic acid in the connective tissues.  It occurs in alkaptonuria, but has also been observed in connection with exposure to certain chemicals (e.g., phenol, trinitrophenol, resorcinol, mercury, picric acid, benzene, hydroquinone, and antimalarials).

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