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Image Number 603 (Sebaceous carcinoma)


Diagnosis: Sebaceous carcinoma

Site: Eyelids

Sex: F

Age: 55

Type: Histology

Description: Low power view infiltrating carcinoma with in situ epidermal component

Submitted by: Nasuhi Engin Aydin

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Differential Diagnosis

History: 55 year old woman with enlarging eyelid mass, about 2cm. Biopsy revealed sebaceous carcinoma which must be differentiated from squamous cell carcinoma (and sometimes from basal cell carcinoma) due to different clinical consequences. Sebaceous carcinoma of the periorbital region can be a diagnostic challenge for the clinican and pathologist. Immunohistochemistry may help in this regard ( see reference Sinard JH, Archives of Opthalmology, 117:776-83, 1999).

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