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Image Number 833 (Kyrle disease)


Diagnosis: Kyrle disease

Site: Hand,dorsum

Sex: F

Age: 60

Type: Clinical

Description: Erythematous papules each with a central keratotic plug

Submitted by: Shahbaz Janjua

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Differential Diagnosis


Kyrle disease is a rare disorder of keratinization which was was first described in 1916 by Kyrle.  The disease is characterized by the formation of large papules with central keratin plugs that may develop in a widespread distribution pattern.  Kyrle's disease is usually associated with a chronic systemic disorder, most commonly chronic renal parenchymal disease.

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