This lady presented with sudden severe swelling of both periorbital regions and lips associated with purpuric lesions on both lower limbs of 3 days duration. She had no history of similar attacks, drug intake or family history of similar condition. Angioedema is a variant of urticaria that primarily affects the subcutaneous tissues, so that the swelling is less demarcated and less red than an urticarial wheal. Angioedema most commonly occurs at junctions between skin and mucous membranes (e.g. peri-orbital, peri-oral and genital). It may be associated with swelling of the tongue and laryngeal mucosa.