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Image Number 1857 (Chemotherapy-induced acral erythema)


Diagnosis: Chemotherapy-induced acral erythema

Site: Hand,dorsum

Sex: M

Age: 62


Description: Painful erythematous plaques.

Submitted by: Nameer Al-Sudany

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Differential Diagnosis


Palmoplantar erythrodysesthesia syndrome is a relatively common syndrome induced by many chemotherapeutic agents, most frequently 5-fluouracil (5-FU),doxorubicin, and cytosine arabinoside. The reaction which is dose-dependent may occur in as many as 40% of treated patients.

The current case is a 62-year-old man with chronic lymphocytic leukemia who few days after starting chemotherapy  complained of dysesthesia of the palms. This is followed in a few days by painful, symmetric dusky erythema and edema of the palms and less severe reaction on the dorsal surface of both hands. 

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