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Image Number #5573 (Kyrle disease)

Diagnosis: Kyrle disease

Description: Multiple keratotic papules

Morphology: Papules

Site: Thigh

Sex: F

Age: 45

Type: Clinical

Submitted By: Ian McColl

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Differential Diagnosis
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History:

This patient had diabetes and renal failure. She had developed these papules over a period of 12 months. They were itchy.This is Kyrle disease, or acquired perforating dermatosis.The characteristic papules have a keratotic plug made up of neutrophils with eliminated collagen and elastin which is being expelled through the epidermis. It is usually seen on the extensor surfaces of the lower extremities. The condition can completely disappear after renal transplantation.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Kyrle disease"

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