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Image Number #890 (Systemic amyloidosis)

Diagnosis: Systemic amyloidosis

Description: Swollen tongue

Morphology: Swelling

Site: Tongue

Sex: F

Age: 75

Type: Clinical

Submitted By: Ian McColl

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Differential Diagnosis
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History:

Systemic amyloidosis is usually asssociated with underlying plasma cell dyscrasias.In this lady's case she had Multiple myeloma.The fibrils of amyloid are made up of immunoglobulin light chains which infiltrate superficial blood vessels causing hemorrhage with mild trauma.The tongue can be uniformly thickened or studded with papules or plaques of amyloid.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Systemic amyloidosis"

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