History:

Paget’s disease of the nipple and areola represents an intraepithelial spread of an adenocarcinoma arising from an intraductal breast carcinoma.The main clinical feature of Paget’s disease is a unilateral,
chronic scaly, eczematous, therapy-resistant, slowly increasing erythema of the nipple and the surrounding skin. On histopathologic examination, there are intraepidermal larger cytoplasmic pale cells with an atypical nucleus, which are named Paget cells. These cells represent intraepithelial single-cell extensions of an intraductal breast carcinoma.